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Kamagra Oral Jelly – recommendations for use and dosage
Kamagra Oral Jelly – Jelly for oral administration with pineapple and orange flavor 50 mg and 100 mg with the active ingredient sildenafil and excipients: sucrose, sodium methyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, acesulfame potassium, sodium chloride, propylene glycol, liquid sorbitol (70%), sodium carmellose, anhydrous citric acid, citric acid monohydrate, sunset yellow FCF (E110), orange flavor or pineapple flavor, purified water. A homogeneous jelly of orange (orange flavor) or yellow color (pineapple flavor), with a sweet taste and pleasant aroma.
One sachet is for one-time use only: open the sachet and use all contents. Kamagra should be taken as needed about an hour before sexual intercourse. The recommended dose of the drug is 50 mg and taken before meals. Depending on the effectiveness and tolerability of the drug, its dose can be increased to 100 mg or reduced to 25 mg. The maximum recommended dose of the drug is 100 mg. The maximum recommended frequency of taking the drug is 1 time per day.
- For mild to moderate renal failure (creatinine clearance 30–80 ml/min), no adjustment of the recommended dose is required. Due to the fact that in patients with severely impaired renal function (creatinine clearance)
- In patients with liver failure, the dose of Kamagra can be reduced to 25 mg.
- In elderly patients, no dose adjustment is required. Kamagra is not indicated for use in patients under 18 years of age.
Pharmacokinetics of Kamagra Oral Jelly
Kamagra Oral Jelly is quickly absorbed. Maximum plasma concentrations are observed 30–120 minutes (average 60 minutes) after administration on an empty stomach. When sildenafil is taken concomitantly with a fatty meal, the extent of absorption is significantly reduced, with an average delay in Tmax of 60 minutes and an average decrease in Cmax of 29%. The mean volume of distribution of sildenafil at steady state (Vss) is 105 L, indicating tissue distribution. Sildenafil and its main circulating metabolite, N-desmethyl metabolite, are approximately 96% bound to plasma proteins. Plasma protein binding depends on the total concentration of the drug.
Kamagra Oral Jelly is excreted primarily through the liver microsomal isoenzymes CYP3A4 (the main route of metabolism) and CYP2C9 (the minor route of metabolism). It is converted to its active metabolite by N-desmethylation and then undergoes further metabolism. This metabolite has similar selectivity for PDE and in vitro activity for PDE5, which is ~50% of the parent drug. Sildenafil is excreted as metabolites mainly in feces (~80%) and to a lesser extent in urine (~13%).
Use in patients taking other medications:
When used together with ritonavir, the maximum single dose of the drug should be 25 mg no more than 1 time within 48 hours. When used together with cytochrome P450 3A4 inhibitors (such as erythromycin, saquinavir, ketoconazole, itraconazole), the initial dose of the drug is 25 mg. To reduce the risk of postural hypotension in patients receiving alpha-blockers, patients receiving alpha-blockers should be stabilized. In addition, it is possible to use the drug starting with a dose of 25 mg.