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Brand Levitra – recommendations for use and dosage
Before you start taking medications used to treat erectile dysfunction, you need to know the condition of your heart and vascular system. Levitra and other vardenafil drugs (Brand Levitra, Generic Levitra, Levitra with Dapoxetine, Levitra Oral Jelly, Levitra Soft) are no exception.
During sexual intercourse, there is a risk of developing heart complications, since vardenafil has vasodilating properties. Older men or men with underlying cardiovascular disease should use medications to treat erectile dysfunction only as directed by a doctor.
It is known that when Levitra is used in a dose of 10 mg, the effectiveness of vardenafil in the treatment of erectile dysfunction occurs with the least side effects in this category of patients.
How does the active ingredient in Levitra work?
Penile erection is a hemodynamic process based on the relaxation of the smooth muscles of the corpora cavernosa and the arterioles located there. During sexual stimulation, nitric oxide (NO) is released from the nerve endings of the corpora cavernosa, which leads to an increase in the content of cyclic guanosine monophosphate (cGMP) in the cavernous bodies. As a result, the smooth muscles of the corpora cavernosa relax, increasing blood flow to the penis. By blocking PDE-5, which is involved in the breakdown of cGMP, vardenafil enhances the local action of endogenous nitric oxide (NO) in the cavernous bodies. An increase in cGMP levels due to PDE5 inhibition leads to relaxation of the smooth muscles of the cavernous bodies and increased blood flow to them. This effect determines Levitra®’s ability to enhance the natural response to sexual stimulation.
Taking vardenafil at a dose of 20 mg causes an erection (sufficient for penetration) within 15 to 20 minutes. A complete response was received within 25 minutes. After oral administration, the Levitra tablet is quickly absorbed. When taken on an empty stomach, an early peak Cmax may be achieved after 15 minutes, but in 90% of cases, on average, Cmax is achieved after 60 minutes. Levitra – how to take When taking vardenafil with a meal containing a large amount of fat, the rate of absorption decreases with an increase to 60 minutes, and the Cmax value decreases by an average of 20%. When taken with regular food containing no more than 30% fat, the pharmacokinetic parameters of vardenafil (Cmax, Tmax, AUC) do not change. Take orally with water, regardless of food.
At the beginning of treatment, the recommended dose is 10 mg approximately one hour before sexual intercourse. Levitra is also effective if taken 3-4 hours before sexual activity. Sexual stimulation is necessary to ensure an adequate response to treatment. The maximum frequency of taking the drug is no more than 1 time per day.
Depending on the effectiveness, the dose may be increased to 20 mg or reduced to 5 mg. The maximum recommended dose is 20 mg once daily.
Levitra Soft (sublingual) should be kept on the tongue until completely dissolved or chewed and then swallowed.
Levitra should not be taken with certain medications due to potential interactions that can lead to adverse effects. Here are some classes of medications that should not be taken with Levitra:
- Nitrates: Drugs containing nitrates, such as nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate, are contraindicated with Levitra. Concurrent use can cause a severe drop in blood pressure, leading to dizziness, fainting, or even a heart attack.
- Alpha-blockers: Medications used to treat high blood pressure or prostate enlargement, such as doxazosin, prazosin, and terazosin, should not be taken with Levitra. Combining Levitra with alpha-blockers can cause a sudden decrease in blood pressure, resulting in dizziness or fainting.
- Other Erectile Dysfunction Medications: Using Levitra with other drugs used to treat erectile dysfunction, such as Viagra (sildenafil) or Cialis (tadalafil), is not recommended due to the increased risk of side effects and potential interactions.
- Recreational Drugs: Recreational drugs containing amyl or butyl nitrite, commonly known as “poppers,” should not be combined with Levitra. These drugs can also cause a dangerous drop in blood pressure when used together.
- Hypertension Medications: Certain medications used to treat high blood pressure, such as alpha-blockers, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors, may interact with Levitra, leading to a further decrease in blood pressure.
Always consult with your healthcare provider or pharmacist before starting Levitra or any other medication to ensure it is safe and appropriate for you, especially if you are taking other medications or have underlying medical conditions.